| Type: | Domain | Name: | Rap GTPase activating protein domain |
| Description: | Rap small G proteins have been implicated in various cellular processes such as exocytosis, cAMP signalling, cell adhesion and cell proliferation. Rapproteins acts as molecular switches, with an active GTP-bound form and an inactive GDP-bound form []. The inactive GDP bound form is promoted byGTPase-activating proteins (GAPs). GAP proteins specific for Rap contain a conserved region of around 200 amino-acid residues, the RapGAP domain. Thisdomain can accelerate the GTP hydrolysis activity of Rap by five orders of magnitude [].Proteins known to contain a Rap-GAP domain include: RAP1 GTPase activating protein (RAP1GAP).Mammalian tuberin protein, the product of a familial tuberous sclerosis gene which, when deleted, causes begnin tumours. It also have a GAPactivity for Rab5 [].Drosophila Gigas protein, an homologue of tuberin involved in regulation of cell cycle.Mammalian tuberin-like protein TULIP.GTPase-activating protein Spa-1. It functions as a negative regulator for the activation of Rap1, thereby having a negative effect on cell adhesion[]. | Short Name: | Rap_GAP_dom |
