Protein Domain : IPR027133

Type:  Family Name:  TNF receptor-associated factor 2
Description:  TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis [, ].TRAF2 is heavily regulated by ubiquitin signals. It has E3 ubiquitin-protein ligase activity and promotes K63-linked ubiquitination of target proteins. Alternatively, TRAF2 may be required for recruiting other E3 ligases, such as A20, to help processing and turnover. Furthermore, TRAF2 is regulated by both K63 and K48 type ubiquitin chains. K63 linkage may be mediated by TRAF2 auto-ubiquitination, and is required for TRAF2 activation. c-IAPl and Siah2 are known E3 ligases that can K48-ubiquitinate TRAF2 to target it for proteasome-dependent degradation [, , ]. Short Name:  TRAF2
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10131:SF21

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0004842 IPR027133
GO:0007250 IPR027133
GO:0033209 IPR027133
GO:0042981 IPR027133
GO:0046328 IPR027133
GO:0051865 IPR027133

6 Ontology Annotations

GO Term Gene Name
GO:0004842 IPR027133
GO:0007250 IPR027133
GO:0033209 IPR027133
GO:0042981 IPR027133
GO:0046328 IPR027133
GO:0051865 IPR027133

1 Parent Features

DB identifier Type Name
IPR012227 Family TNF receptor-associated factor TRAF

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            17633015
            15258597
            10346818
            18981220
            20577214