Protein Domain : IPR027136

Type:  Family Name:  TNF receptor-associated factor 1
Description:  TNF receptor-associated factor 1 (TRAF1) is an adapter molecule that regulates the activation of NF-kappa-B and JNK. TRAF1 plays a role in the regulation of cell survival and apoptosis []. TRAF1 is unique among TRAF proteins in that it lacks RING domain found in the N-terminal regions of other TRAFs []. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14 [, ]. Short Name:  TRAF1
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10131:SF29

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0007165 IPR027136
GO:0042981 IPR027136
GO:0051092 IPR027136

3 Ontology Annotations

GO Term Gene Name
GO:0007165 IPR027136
GO:0042981 IPR027136
GO:0051092 IPR027136

1 Parent Features

DB identifier Type Name
IPR012227 Family TNF receptor-associated factor TRAF

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            20385093
            10692572
            17633014
            18429822