Protein Domain : IPR012224

Type:  Family Name:  Peptidase S1A, coagulation factor VII/IX/X/C/Z
Description:  This group of plasma glycoproteins includes coagulation factors VII, IX, and X, and proteins C and Z, which belong to MEROPS peptidase family S1, subfamily S1A (chymotrypsin, clan PA(S)). All but protein Z are peptidases and are involved in blood coagulation. The precursors contain a signal sequence, propeptide, Gla domain, two EGF domains (although sometimes only one is detected by Pfam), and a trypsin domain. Except for protein Z, they are further cleaved between the second EGF domain and the trypsin domain into light and heavy chains, which are connected by a disulphide bond. Glutamic acid residues in the Gla domain undergo vitamin K-dependent carboxylation, allowing this region to bind calcium and membrane phospholipid []. The propeptide region is important in providing a recognition site for the gamma-carboxylase []. Typically one aspartic acid residue in the light chain is post-translationally modified to erythro-beta-hydroxyaspartic acid [, ]. Short Name:  Pept_S1A_FX
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0 Child Features

5 Contains

DB identifier Type Name
IPR000742 Domain EGF-like domain
IPR013032 Conserved_site EGF-like, conserved site
IPR000294 Domain Gamma-carboxyglutamic acid-rich (GLA) domain
IPR018097 Conserved_site EGF-like calcium-binding, conserved site
IPR018114 Active_site Peptidase S1, trypsin family, active site

1 Cross References

Identifier
PIRSF001143

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004252 IPR012224
GO:0005509 IPR012224
GO:0007596 IPR012224

3 Ontology Annotations

GO Term Gene Name
GO:0004252 IPR012224
GO:0005509 IPR012224
GO:0007596 IPR012224

1 Parent Features

DB identifier Type Name
IPR001314 Family Peptidase S1A, chymotrypsin-type

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8663165
            6630196
            6688526
            10358041