Protein Domain : IPR000233

Type:  Domain Name:  Cadherin, cytoplasmic domain
Description:  Cadherins are transmembrane glycoproteins vital in calcium-dependent cell-cell adhesion during tissue differentiation []. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn []. The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, possibly through interaction with the cytoskeleton []. This domain is found upstream of the cadherin domain . Short Name:  Cadherin_cytoplasmic-dom
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0 Child Features

0 Contains

1 Cross References

Identifier
PF01049

2 Found Ins

DB identifier Type Name
IPR009122 Family Desmosomal cadherin
IPR009123 Family Desmoglein

3 GO Annotations

GO Term Gene Name
GO:0005509 IPR000233
GO:0007156 IPR000233
GO:0016020 IPR000233

3 Ontology Annotations

GO Term Gene Name
GO:0005509 IPR000233
GO:0007156 IPR000233
GO:0016020 IPR000233

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9566976
            3061804