Protein Domain : IPR003074

Type:  Family Name:  Peroxisome proliferator-activated receptor
Description:  Steroid or nuclear hormone receptors (4A nuclear receptor, NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone, retinoids, 1,25-dihydroxy-vitamin D3 and a variety of other ligands []. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner [, ]. In addition to C-terminal ligand-binding domains, these nuclear receptors contain a highly-conserved, N-terminal zinc-finger that mediates specific binding to target DNA sequences, termed ligand-responsive elements. In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity.NRs are extremely important in medical research, a large number of them being implicated in diseases such as cancer, diabetes, hormone resistance syndromes, etc. While several NRs act as ligand-inducible transcription factors, many do not yet have a defined ligand and are accordingly termed 'orphan' receptors. During the last decade, more than 300 NRs have been described, many of which are orphans, which cannot easily be named due to current nomenclature confusions in the literature. However, a new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.Peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Three cDNAs encoding PPARs have been isolated from Xenopus laevis: xPPAR alpha, beta and gamma []. All three xPPARs appear to be activated by both synthetic peroxisome proliferators and naturally occurring fatty acids, suggesting a common mode of action for all members of this subfamily of receptors []. Furthermore, the multiplicity of the receptors suggests the existence of hitherto unknown cellular signalling pathways for xenobiotics and putative endogenous ligands []. Synonym(s): 1C nuclear receptor Short Name:  1Cnucl_rcpt
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3 Child Features

DB identifier Type Name
IPR003075 Family Peroxisome proliferator-activated receptor, beta
IPR003076 Family Peroxisome proliferator-activated receptor, alpha
IPR003077 Family Peroxisome proliferator-activated receptor, gamma

1 Contains

DB identifier Type Name
IPR000536 Domain Nuclear hormone receptor, ligand-binding domain

1 Cross References

Identifier
PR01288

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR003074
GO:0004879 IPR003074
GO:0006355 IPR003074
GO:0005634 IPR003074

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR003074
GO:0004879 IPR003074
GO:0006355 IPR003074
GO:0005634 IPR003074

1 Parent Features

DB identifier Type Name
IPR001723 Family Nuclear hormone receptor

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7899080
            8165128
            14747695
            1312391
            8274443