3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0018024 | IPR017111 |
| GO:0034968 | IPR017111 |
| GO:0048188 | IPR017111 |
| Type: | Family | Name: | Histone H3-K4 methyltransferase Set1, fungal |
| Description: | This entry represents fungal-type histone H3-K4 methyltransferase Set1 (), which is the catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation [, , ]. The COMPASS (Set1C) complex consists of SET1(2), BRE2(2), SPP1(2), SDC1(1),SHG1(1), SWD1(1), SWD2(1), and SWD3(1) [, , , ].Methyltransferases (EC 2.1.1.-) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [, , ]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM []. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [, , ]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [, , ]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor. | Short Name: | Hist_H3-K4_MeTrfase_1_fun |
| GO Term | Gene Name |
|---|---|
| GO:0018024 | IPR017111 |
| GO:0034968 | IPR017111 |
| GO:0048188 | IPR017111 |
