| Type: | Conserved_site | Name: | Zinc finger, XPA-type, conserved site |
| Description: | Xeroderma pigmentosum (XP) [] is a human autosomal recessive disease,characterised by a high incidence of sunlight-induced skin cancer. Skin cells of individual's with this condition are hypersensitive to ultraviolet light, due to defects in the incision step of DNA excision repair. There are a minimum ofseven genetic complementation groups involved in this pathway: XP-A to XP-G. XP-A is the most severe form of the disease and is due to defects in a 30 kDanuclear protein called XPA (or XPAC) [].The sequence of the XPA protein is conserved from higher eukaryotes [] toyeast (gene RAD14) []. XPA is a hydrophilic protein of 247 to 296 amino-acidresidues which has a C4-type zinc finger motif in its central section. This entry contains the zinc-finger containing region in the XPA protein. It is found N-terminal to | Short Name: | Znf_XPA_CS |
