| Type: | Binding_site | Name: | Inositol monophosphatase, metal-binding site |
| Description: | It has been shown that several proteins share two sequence motifs []. Two of theseproteins, vertebrate and plant inositol monophosphatase (), and vertebrate inositol polyphosphate 1-phosphatase (), are enzymes of the inositol phosphate second messenger signalling pathway, and share similar enzyme activity. Both enzymes exhibit an absolute requirementfor metal ions (Mg2+is preferred), and their amino acid sequences contain a number of conserved motifs, which are also shared by several other proteins related to MPTASE (including products of fungal QaX and qutG, bacterial suhB and cysQ, and yeast hal2) []. The function of theother proteins is not yet clear, but it is suggested that they may act by enhancing the synthesis or degradation of phosphorylated messenger molecules []. Structural analysis of theseproteins has revealed a common core of 155 residues, which includes residues essential for metal binding and catalysis. An interesting property of the enzymes of this family is their sensitivityto Li+. The targets and mechanism of action of Li+are unknown, but overactive inositol phosphate signalling may account for symptoms of manic depression [].This entry represents the metal-binding site found within the inositol monophosphatase family of proteins. It is suggested [] that these proteins may act by enhancing the synthesis or degradation of phosphorylated messenger molecules. The signature pattern of this entry contains the aspartic and threonine residues involved in binding a metal ion []. | Short Name: | Inositol_monoP_metal-BS |
| DB identifier | Type | Name |
|---|---|---|
| IPR011809 | Family | Histidinol-phosphate phosphatase, putative, inositol monophosphatase |
| IPR000760 | Family | Inositol monophosphatase |
| IPR006239 | Family | 3(2),5 -bisphosphate nucleotidase HAL2 |
| IPR020552 | Family | Inositol monophosphatase, Lithium-sensitive |
| IPR022337 | Family | Inositol monophosphatase, SuhB |
| IPR006240 | Family | 3(2),5 -bisphosphate nucleotidase, bacterial |
| IPR021175 | Family | Bifunctional inorganic polyphosphate/ATP-NAD kinase, predicted |
