1 Contains
| DB identifier | Type | Name |
|---|---|---|
| IPR011250 | Domain | Outer membrane protein/outer membrane enzyme PagP, beta-barrel |
| Type: | Family | Name: | Virulence-related outer membrane protein |
| Description: | Virulence-related outer membrane proteins are expressed in Gram-negative bacteria and are essential to bacterial survival within macrophages and for eukaryotic cell invasion. Members of this group include: PagC, required by Salmonella typhimuriumfor survival in macrophages and for virulence in mice []Rck outer membrane protein of the S. typhimurium virulence plasmid []Ail, a product of the Yersinia enterocoliticachromosome capable of mediating bacterial adherence to and invasion of epithelial cell lines []OmpX from Escherichia colithat promotes adhesion to and entry into mammalian cells. It also has a role in the resistance against attack by the human complement system []a Bacteriophage lambdaouter membrane protein, Lom []The crystal structure of OmpX from E. coli reveals that OmpX consists of an eight-stranded antiparallel all-next-neighbour beta barrel []. The structure shows two girdles of aromatic amino acid residues and a ribbon of nonpolar residues that attach to the membrane interior. The core of the barrel consists of an extended hydrogen-bonding network of highly conserved residues. OmpX thus resembles an inverse micelle. The OmpX structure shows that the membrane-spanning part of the protein is much better conserved than the extracellular loops. Moreover, these loops form a protruding beta sheet, the edge of which presumably binds to external proteins. It is suggested that this type of binding promotes cell adhesion and invasion and helps defend against the complement system. Although OmpX has the same beta-sheet topology as the structurally related outer membrane protein A (OmpA) , their barrels differ with respect to the shear numbers and internal hydrogen-bonding networks. | Short Name: | Enterovir_OMP |
| DB identifier | Type | Name |
|---|---|---|
| IPR011250 | Domain | Outer membrane protein/outer membrane enzyme PagP, beta-barrel |
