| Type: | Family | Name: | D-alanyl-D-alanine dipeptidase |
| Description: | This group of metallopeptidases belong to MEROPS peptidase family M15 (clan MD), subfamily M15D (vanX D-Ala-D-Ala dipeptidase).The D-alanyl-D-alanine dipeptidase enzyme from Enterococcus faecalisis also known as the vancomycin resistance protein VanX, and hydrolyses D-ala-D-ala. It has a 250-fold differential in catalytic efficiency for hydrolysis of D-ala-D-ala versus D-ala-D-lactate. The latter therefore remains intact for subsequent incorporation into peptidoglycan precursors that terminate in the dipeptide D-ala-D-lactate rather than the dipeptide D-ala-D-ala, thereby preventing vancomycin from binding. The enzyme requires a metal cofactor, and is induced by vancomycin through regulation by VanS and VanR. | Short Name: | A_A_dipeptidase |
| DB identifier | Type | Name |
|---|---|---|
| IPR009045 | Domain | Hedgehog signalling/DD-peptidase zinc-binding domain |
| GO Term | Gene Name |
|---|---|
| GO:0008237 | IPR000755 |
| GO:0016805 | IPR000755 |
| GO:0006508 | IPR000755 |
| GO:0005618 | IPR000755 |
| GO Term | Gene Name |
|---|---|
| GO:0008237 | IPR000755 |
| GO:0016805 | IPR000755 |
| GO:0006508 | IPR000755 |
| GO:0005618 | IPR000755 |
