Protein Domain : IPR006180

Type:  Conserved_site Name:  3-hydroxyacyl-CoA dehydrogenase, conserved site
Description:  3-hydroxyacyl-CoA dehydrogenase () (HCDH) [] is an enzyme involved in fatty acid metabolism, it catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA. Most eukaryotic cells have 2 fatty-acid beta-oxidation systems, one located in mitochondria and the other in peroxisomes. In peroxisomes 3-hydroxyacyl-CoA dehydrogenase forms, with enoyl-CoA hydratase (ECH) and 3,2-trans-enoyl-CoA isomerase (ECI) a multifunctional enzyme where the N-terminal domain bears the hydratase/isomerase activities and the C-terminal domain the dehydrogenase activity. There are two mitochondrial enzymes: one which is monofunctional and the other which is, like its peroxisomal counterpart, multifunctional.In Escherichia coli(gene fadB) and Pseudomonas fragi(gene faoA) HCDH is part of a multifunctional enzyme which also contains an ECH/ECI domain as well as a 3-hydroxybutyryl-CoA epimerase domain [].The other proteins structurally related to HCDH are:Bacterial 3-hydroxybutyryl-CoA dehydrogenase () which reduces 3-hydroxybutanoyl-CoA to acetoacetyl-CoA [].Eye lens protein lambda-crystallin [], which is specific to lagomorphes (such as rabbit).There are two major region of similarities in the sequences of proteins of the HCDH family, the first one located in the N-terminal, corresponds to the NAD-binding site, the second one is located in the centre of the sequence. Short Name:  3-OHacyl-CoA_DH_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00067

7 Found Ins

DB identifier Type Name
IPR013328 Domain 6-phosphogluconate dehydrogenase, domain 2
IPR008927 Domain 6-phosphogluconate dehydrogenase C-terminal domain-like
IPR006108 Domain 3-hydroxyacyl-CoA dehydrogenase, C-terminal
IPR022694 Family 3-hydroxyacyl-CoA dehydrogenase
IPR012802 Family Fatty oxidation complex, alpha subunit FadJ
IPR012799 Family Fatty oxidation complex, alpha subunit FadB
IPR011967 Family 3-hydroxyacyl-CoA dehydrogenase PaaC

4 GO Annotations

GO Term Gene Name
GO:0003857 IPR006180
GO:0016491 IPR006180
GO:0006631 IPR006180
GO:0055114 IPR006180

4 Ontology Annotations

GO Term Gene Name
GO:0003857 IPR006180
GO:0016491 IPR006180
GO:0006631 IPR006180
GO:0055114 IPR006180

0 Parent Features

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2204034
            3479790
            8001771
            3170592