| Type: | Family | Name: | Predicted nickel metalloenzyme maturation factor, AIR synthase-related |
| Description: | The large subunit of [NiFe]-hydrogenase--as well as other nickel metalloenzymes--is synthesized as a precursor devoid of the metalloenzyme active site. This precursor then undergoes a complex post-translational maturation process that requires a number of accessory proteins [, ].One such group of accessory proteins is represented by , whose members are required for hydrogenase maturation [, ] (though their exact function is still unknown). Proteins from this family have similar sequences to members. Thus, members of this family are predicted to play a role in maturation of some nickel metalloenzyme(s). However, other functions can not be ruled out. Both this family and are related to proteins that use both purine derivatives and ATP as substrates. They belong to a superfamily of AIR synthase-related proteins that also includes PurM phosphoribosylaminoimidazole synthetase (AIR synthase, ), thiamine monophosphate kinase (), phosphoribosylformylglycinamidine synthase (FGAM synthase, ), and selenophosphate synthase (selenide, water dikinase). | Short Name: | Ni_metllenz_mat |
