Protein Domain : IPR029761

Type:  Family Name:  Pyroglutamyl peptidase I, metazoa
Description:  This group of cysteine peptidases belong to MEROPS peptidase family C15 (pyroglutamyl peptidase I, clan CF). The type example being pyroglutamyl peptidase I of Bacillus amyloliquefaciens. Pyroglutamyl/pyrrolidone carboxyl peptidase (Pcp or PYRase) is an exopeptidase that hydrolytically removes the pGlu from pGlu-peptides or pGlu-proteins [, ].PYRase has been found in prokaryotes and eukaryotes where at least two different classes have been characterised: the first containing bacterial and animal type I PYRases, and the second containinganimal type II and serum PYRases. Type I and bacterial PYRases are solubleenzymes, while type II PYRases are membrane-bound. The primary application of PYRase has been its utilisation for protein or peptide sequencing, andbacterial diagnosis []. The conserved residues Cys-144 and His-168 havebeen identified by inhibition and mutagenesis studies [, ].This family consists of the animal type I PYRases [, ]. In mammals, this enzyme may be involved in the inactivation of biologically active peptides that contain an N-terminal pyroglutamyl residue (such as neurotensin, LHRH3 and thyrotropin-releasing hormone) []. Short Name:  PGP-I_metazoa
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR23402:SF11

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0008233 IPR029761
GO:0016920 IPR029761
GO:0006508 IPR029761
GO:0005829 IPR029761

4 Ontology Annotations

GO Term Gene Name
GO:0008233 IPR029761
GO:0016920 IPR029761
GO:0006508 IPR029761
GO:0005829 IPR029761

1 Parent Features

DB identifier Type Name
IPR000816 Family Peptidase C15, pyroglutamyl peptidase I

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1353026
            7909543
            7824521
            14600395
            12651114