| Type: | Family | Name: | T-cell surface antigen CD4 |
| Description: | CD4 is a glycoprotein found on the surface of T cells. It is a co-receptor that assists the T cell receptor (TCR) in communicating with an antigen-presenting cell (APC). The structure of a soluble fragment of CD4 has been determined to 2.3 A and reveals that the molecule has two intimately-associated immunoglobulin-like domains connected by a continuous beta strand. Residues implicated in HIV recognition reside in domain D1. Domain D2 is distinguished by a variation in the beta-strand topologies of antibody domains that results in a truncated beta-barrel with a non-standard intra-sheet disulphide bond [, ]. The binding sites for monoclonal antibodies, class II major histocompatibility complex molecules, and HIV gp120 can be mapped on the molecular surface. | Short Name: | CD4 |
| DB identifier | Type | Name |
|---|---|---|
| IPR013783 | Domain | Immunoglobulin-like fold |
| IPR007110 | Domain | Immunoglobulin-like domain |
| IPR003599 | Domain | Immunoglobulin subtype |
| IPR013151 | Domain | Immunoglobulin |
| IPR013106 | Domain | Immunoglobulin V-set domain |
| IPR008424 | Domain | Immunoglobulin C2-set |
| IPR015274 | Domain | CD4, extracellular |
| IPR021963 | Domain | T cell CD4 receptor C-terminal region |
| GO Term | Gene Name |
|---|---|
| GO:0015026 | IPR000973 |
| GO:0006955 | IPR000973 |
| GO:0016020 | IPR000973 |
