| Type: | Family | Name: | 7-carboxy-7-deazaguanine synthase, Clostridial form |
| Description: | This entry represents Clostridial form of the 7-carboxy-7-deazaguanine synthases. They are encoded in preQ0 operons found in species that lack members of the related protein family . 7-deazapurines are compounds that contain pyrrolopyrimidine functional groups (similar to purines, but lacking one of the nitrogens in the pentameric ring). These compounds form a structurally diverse class of nucleoside analogues that often possess antibiotic, antineoplastic, or antiviral activities. Examples of 7-deazapurines that are important for cell function include the bacterial/eukaryotic modified tRNA base queuosine and the archaeal modified base archaeosine. 7-cyano-7-deazaguanosine (preQ0) is the precursor for all 7-deazapurines and is produced from GTP in a four-step pathway [, ]. 7-carboxy-7-deazaguanine synthase catalyses the third step in this pathway, the conversion of 6-carboxy-5,6,7,8-tetrahydropterin to 7-carboxy-7-deazaguanine. | Short Name: | 7-CO-7-deazaGua_synth_put_Clo |
