| Type: | Family | Name: | Tumour necrosis factor receptor 17 |
| Description: | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based onsimilarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern []. Thecysteines allow formation of an extended rod-like structure, responsible for ligand binding [].Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on theirintracellular domains and sequences []. Activation of TNFRs can thereforeinduce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon thereceptor involved [].TNFRs are widely distributed and play important roles in many crucial biological processes, such as lymphoid and neuronal development, innate andadaptive immunity, and maintenance of cellular homeostasis []. Drugs that manipulate their signalling have potential roles in the prevention andtreatment of many diseases, such as viral infections, coronary heart disease, transplant rejection, and immune disease [].TNF receptor 17 acts as a receptor for both a proliferation-inducing ligand (APRIL) and B cell-activating factor (BAFF) []. It is preferentially expressed by mature B-cells, suggesting a potential role for the receptor in the B-cell developmental process []. | Short Name: | TNFR_17 |
