Protein Domain : IPR000842

Type:  Conserved_site Name:  Phosphoribosyl pyrophosphate synthetase, conserved site
Description:  Phosphoribosyl pyrophosphate synthetase () (PRib-PP synthetase) catalyses the formation of PRib-PP from ATP and ribose 5-phosphate. PRib-PP is then used in various biosynthetic pathways, for example in the formation of purines, pyrimidines, histidine and tryptophan. PRib-PP synthetase requires inorganic phosphate and magnesium ions for its stability and activity. In mammals, three isozymes of PRib-PP synthetase are found, while in yeast there are at least four isozymes. A very conserved region containing two conserved aspartic acid residues as well as a histidine has been suggested to be involved in binding divalent cations []. These residues are all potential ligands for a cation such as magnesium. Short Name:  PRib_PP_synth_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00114

1 Found In

DB identifier Type Name
IPR005946 Family Ribose-phosphate diphosphokinase

4 GO Annotations

GO Term Gene Name
GO:0000287 IPR000842
GO:0004749 IPR000842
GO:0009156 IPR000842
GO:0044249 IPR000842

4 Ontology Annotations

GO Term Gene Name
GO:0000287 IPR000842
GO:0004749 IPR000842
GO:0009156 IPR000842
GO:0044249 IPR000842

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2542328