Protein Domain : IPR000837

Type:  Family Name:  AP-1 transcription factor
Description:  The transcription factor activator protein (AP)-1 consists of Jun (c-Jun, JunB, and JunD), Fos (c-Fos, FosB, Fra1, and Fra2), ATF and JDP family members []. They are basic leucine zipper transcription factors that play a central role in regulating gene transcription in various biological processes []. This entry includes Fos, ATF-3 and JDP family members. AP-1 proteins have a alpha-helical bZIP domain, which contains a basic DNA-binding region and regularly spaced leucine residues known as the leucine zipper motif []. They have similar protein structure and can either form homodimers or form heterodimers with other AP-1 proteins (predominantly with Jun proteins), which can then bind to TRE-like sequences (consensus sequence 5'-TGAG/CTCA-3') []. Each of these proteins are expressed in different tissues and can be regulated in different ways, which means that every cell type has a complex mixture of AP-1 dimers with subtly different functions []. Short Name:  AP-1
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8 Child Features

DB identifier Type Name
IPR029812 Family cAMP-dependent transcription factor ATF-3
IPR029813 Family Protein FosB
IPR029814 Family Fos-related antigen 2
IPR029815 Family Fos-related antigen 1
IPR029816 Family c-Fos/v-Fos
IPR029818 Family Basic leucine zipper transcriptional factor ATF-like 3
IPR029819 Family Jun dimerization protein 2
IPR029820 Family Basic leucine zipper transcriptional factor ATF-like

0 Contains

2 Cross Referencess

Identifier
PTHR23351
PR00042

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003677 IPR000837
GO:0003700 IPR000837
GO:0006357 IPR000837

3 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR000837
GO:0003700 IPR000837
GO:0006357 IPR000837

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12424143
            23787991
            15564374