Protein Domain : IPR015956

Type:  Domain Name:  Penicillin-binding protein-associated
Description:  This entry represents a structural motif found at the C-terminal of penicillin-binding proteins 4 (PBP4) and 5 (PBP5), as well as at the C-terminal of D-Ala-D-Ala carboxypeptidase A, a member of the MEROPS S11 peptidase family (PBP4 and PBP5 also belong to this peptidase family). These domains share a similar structure, consisting of a beta-sandwich of six strands in two sheets [, ].Penicillin-binding proteins are beta-lactam antibiotic-sensitive bacterial enzymes required for the growth and maintenance of the peptidoglycan layer of the bacterial cell wall that protects the cell from osmotic stress. PBP4 functions as a transpeptidase, acting co-operatively with PBP2 in staphylococcal cell wall biosynthesis and susceptibility to antimicrobial agents []. Short Name:  Peniciliin-bd_prot-assoc
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2 Child Features

DB identifier Type Name
IPR012907 Domain Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal
IPR015294 Domain Penicillin-binding protein 4, C-terminal domain

0 Contains

1 Cross References

Identifier
SSF69189

1 Found In

DB identifier Type Name
IPR018044 Family Peptidase S11, D-alanyl-D-alanine carboxypeptidase A

2 GO Annotations

GO Term Gene Name
GO:0004180 IPR015956
GO:0006508 IPR015956

2 Ontology Annotations

GO Term Gene Name
GO:0004180 IPR015956
GO:0006508 IPR015956

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14555648
            15596446
            16411754