Protein Domain : IPR012915

Type:  Family Name:  Reovirus RNA-dependent RNA polymerase lambda 3
Description:  The sequences in this family are similar to the reoviral minor core protein lambda 3 (), which functions as a RNA-dependent RNA polymerase within the protein capsid. It is organised into 3 domains. The N- and C-terminal domains create a "cage" which encloses a conserved central catalytic domain within a hollow centre. This catalytic domain is arranged to form finger, palm and thumb subdomains. Unlike other RNA polymerases, such as HIV reverse transcriptase and T7 RNA polymerase, the lambda 3 protein binds template and substrate with only localised rearrangements, and catalytic activity can occur with little structural change. However, the structure of the catalytic complex is similar to that of other polymerase catalytic complexes with known structure []. Short Name:  RdRP_5
Paste the following link

0 Child Features

1 Contains

DB identifier Type Name
IPR007097 Domain RNA-directed RNA polymerase, reovirus

1 Cross References

Identifier
PF07925

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003723 IPR012915
GO:0003968 IPR012915
GO:0032774 IPR012915
GO:0019013 IPR012915

4 Ontology Annotations

GO Term Gene Name
GO:0003723 IPR012915
GO:0003968 IPR012915
GO:0032774 IPR012915
GO:0019013 IPR012915

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12464184