3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0005248 | IPR008051 |
| GO:0006814 | IPR008051 |
| GO:0001518 | IPR008051 |
1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR001696 | Family | Voltage gated sodium channel, alpha subunit |
| Type: | Family | Name: | Voltage gated sodium channel, alpha-1 subunit |
| Description: | Voltage-dependent sodium channels are transmembrane (TM) proteins responsible for the depolarising phase of the action potential in mostelectrically excitable cells []. They may exist in 3 states []: theresting state, where the channel is closed; the activated state, where the channel is open; and the inactivated state, where the channel is closedand refractory to opening. Several different structurally and functionally distinct isoforms are found in mammals, coded for by a multigene family, these being responsible for the different types of sodium ion currentsfound in excitable tissues. The structure of sodium channels is based on 4 internal repeats of a 6-helix bundle [] (in which 5 of the membrane-spanning segments are hydrophobic andthe other is positively charged), forming a 24-helical bundle. The charged segments are believed to be localised within clusters formed by their 5 hydrophobic neighbours: it is postulated that the charged domain may be the voltage sensor region, possibly moving outward on depolarisation, causing aconformational change. This model [] contrastswith another [], in which the TM segments are juxtaposedoctagonally. The basic structural motif (the 6-helix bundle) is also found in potassium and calcium channel alpha subunits.The SCN1A gene encodes the NaB1 channel and is particularly expressed in the brain, but is also found in a variety of other tissues, ranging from theretina to the olfactory bulb. Epilepsy, a disorder of neuronal hyperexcitability, has been associated with altered kinetics of SCN1A, aswell as delayed inactivation of SCN2A [].This entry represents the alpha 1 subunits of the voltage-gated Na+ channel superfamily. For entries containing other members of this superfamily see , , . | Short Name: | Na_channel_a1su |
| GO Term | Gene Name |
|---|---|
| GO:0005248 | IPR008051 |
| GO:0006814 | IPR008051 |
| GO:0001518 | IPR008051 |
| DB identifier | Type | Name |
|---|---|---|
| IPR001696 | Family | Voltage gated sodium channel, alpha subunit |
