| Type: | Family | Name: | Type VI secretion system, IcmF |
| Description: | Type VI secretion system (T6SS) appears to be confined to Proteobacteria. It is important for bacterial pathogenesis, but it is also found in non-pathogenic bacteria, suggesting that T6SS involvement is not limited to virulence []. T6SS was identified in Vibrio cholerae [] and Pseudomonas aeruginosa [], and exports Hcp (Haemolysin-Coregulated Protein) and a class of proteins named Vgr (Val-Gly Repeats), whose exact function is still speculative. In addition to Vgr and Hcp proteins, T6SS is characterised by the presence of an AAA+ Clp-like ATPase and of two additional genes icmF and dotU, encoding homologues of T4SS stabilising proteins []. Proteins in this entry are IcmF homologues. IcmF is thought to be an inner membrane protein and a component of the T6SS apparatus []. | Short Name: | T6SS_IcmF |
