Protein Domain : IPR003919

Type:  Family Name:  Cellulose synthase, subunit A
Description:  An operon encoding 4 proteins required for bacterial cellulose biosynthesis (bcs) in Acetobacter xylinus(Gluconacetobacter xylinus) has been isolated via genetic complementation with strains lacking cellulose synthase activity []. Nucleotide sequence analysis showed the cellulose synthase operon to consist of 4 genes, designated bcsA, bcsB, bcsC and bcsD, all of which are required for maximal bacterial cellulose synthesis in A. xylinum.The calculated molecular mass of the protein encoded by bcsA is 84.4kDa []. Sequence analysis suggests that the gene product is an integral membrane protein with several transmembrane (TM) domains []. It is postulated that the protein is anchored in the membrane at the N-terminal end by a single hydrophobic helix. Two potential N-glycosylation sites are predicted from sequence analysis, consistent with earlier observations that BcsA is a glycoprotein. The function of BcsA is unknown. The sequence shares a high degree of similarity with Escherichia coliYhjO.Cellulose synthase catalyzes the beta-1,4 polymerisation of glucose residues in the formation of cellulose. In bacteria, the substrate is UDP-glucose. The synthase consists of two subunits (or domains in the frequent cases where it is encoded as a single polypeptide), the catalytic domain modelled here and the regulatory domain (). The regulatory domain binds the allosteric activator cyclic di-GMP [, ]. The protein is membrane-associated and probably assembles into multimers such that the individual cellulose strands can self-assemble into multi-strand fibrils. Short Name:  Cell_synth_A
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0 Child Features

2 Contains

DB identifier Type Name
IPR001173 Domain Glycosyltransferase 2-like
IPR009875 Domain PilZ domain

2 Cross Referencess

Identifier
PR01439
TIGR03030

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0016759 IPR003919
GO:0035438 IPR003919
GO:0006011 IPR003919
GO:0016020 IPR003919

4 Ontology Annotations

GO Term Gene Name
GO:0016759 IPR003919
GO:0035438 IPR003919
GO:0006011 IPR003919
GO:0016020 IPR003919

0 Parent Features

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2146681
            2151718
            18034161
            16920715