Protein Domain : IPR011248

Type:  Family Name:  Serine/alanine racemase
Description:  This family represents a serine/alanine racemase from Enterococcus spp [, ].Vancomycin resistance in Enterococcus gallinarumresults from the production of UDP-MurNAc-pentapeptide[D-Ser]. VanT, a membrane-bound serine racemase, is one of three proteins essential for this resistance. VanT also has alanine racemase activity but it is able to racemize serine more efficiently than alanine. It requires pyridoxal phosphate for activity and there is a highly conserved pyridoxal phosphate attachment site in the C-terminal domain, typical of alanine racemases []. The N-terminal domain contains 10 predicted transmembrane segments and is likely to be involved in the transport of L-Ser, and that in its absence the vancomycin resistance phenotype is compromised []. Short Name:  Serine/alanine_racemase
Paste the following link

0 Child Features

3 Contains

DB identifier Type Name
IPR001608 Domain Alanine racemase, N-terminal
IPR011079 Domain Alanine racemase, C-terminal
IPR020622 Binding_site Alanine racemase, pyridoxal-phosphate attachment site

1 Cross References

Identifier
PIRSF036464

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0016855 IPR011248
GO:0030170 IPR011248
GO:0046677 IPR011248
GO:0016021 IPR011248

4 Ontology Annotations

GO Term Gene Name
GO:0016855 IPR011248
GO:0030170 IPR011248
GO:0046677 IPR011248
GO:0016021 IPR011248

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10878136
            10209740
            12615855