Protein Domain : IPR029580

Type:  Family Name:  Prostaglandin G/H synthase 1
Description:  Prostaglandin G/H synthase 1 (COX-1) and synthase 2 (COX-2) convert arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis []. PGH2 is then metabolised to one of at least five bioactive prostaglandins, including PGE2, PGI2, PGF2alpha, PGD2, or thromboxane A2 (TxA2). These prostanoids have pleiotropic cardiovascular effects altering platelet and renal function, and acting either as vasodilators or vasoconstrictors []. COX-1 and COX-2 are the two cyclooxygenase isozymes targeted by the nonsteroidal anti-inflammatory drugs (NSAIDs) [, ].COX-1 (cyclooxygenase-1) is highly expressed in stomach and platelets, where it catalyses the arachidonic acid (AA) conversion into prostaglandins, which protect the gastrointestinal tract and modulate platelet function []. COX-1 may contribute to ovarian cancer development through stimulation of neovascularisation []. It is also involved in neurodegenerative diseases, such as Alzheimer's [, ]. Short Name:  COX-1
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR11903:SF6

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0004666 IPR029580
GO:0001516 IPR029580
GO:0006954 IPR029580
GO:0008217 IPR029580
GO:0019371 IPR029580

5 Ontology Annotations

GO Term Gene Name
GO:0004666 IPR029580
GO:0001516 IPR029580
GO:0006954 IPR029580
GO:0008217 IPR029580
GO:0019371 IPR029580

1 Parent Features

DB identifier Type Name
IPR019791 Family Haem peroxidase, animal

0 Proteins

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16373578
            24819536
            14630509
            24531199
            12615701
            23083210
            22001217
            12093889