Protein Domain : IPR027185

Type:  Family Name:  Toll-like receptor 2
Description:  Toll-like receptor 2 (TLR2) is a member of the Toll-like receptor (TLR) family, which plays a role in activation of innate immunity and pathogen recognition []. It helps mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components, acting via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [, , , ]. TLR2 in association with TLR1 or TLR6 is essential for recognising bacterial lipoproteins and lipopeptides [, ]. It also promotes apoptosis in response to lipoproteins [].Genetic variations in TLR2 are associated with susceptibility to leprosy, a chronic disease associated with depressed cellular (but not humoral) immunity [, ]. Short Name:  TLR2
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR24365:SF17

0 Found In

8 GO Annotations

GO Term Gene Name
GO:0002237 IPR027185
GO:0002755 IPR027185
GO:0006954 IPR027185
GO:0034134 IPR027185
GO:0045087 IPR027185
GO:0050707 IPR027185
GO:0050729 IPR027185
GO:0016021 IPR027185

8 Ontology Annotations

GO Term Gene Name
GO:0002237 IPR027185
GO:0002755 IPR027185
GO:0006954 IPR027185
GO:0034134 IPR027185
GO:0045087 IPR027185
GO:0050707 IPR027185
GO:0050729 IPR027185
GO:0016021 IPR027185

1 Parent Features

DB identifier Type Name
IPR017241 Family Toll-like receptor

0 Proteins

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10426995
            11680785
            12610729
            17449723
            18177245
            10426996
            11431423
            12077222
            12646604
            12594207