4 GO Annotations
| GO Term | Gene Name |
|---|---|
| GO:0005215 | IPR029387 |
| GO:0046982 | IPR029387 |
| GO:0015721 | IPR029387 |
| GO:0005886 | IPR029387 |
4 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0005215 | IPR029387 |
| GO:0046982 | IPR029387 |
| GO:0015721 | IPR029387 |
| GO:0005886 | IPR029387 |
| Type: | Family | Name: | Organic solute transporter subunit beta |
| Description: | Organic solute transporter subunit beta (OSTbeta, also known as SLC51B) is an essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood [].OSTbeta is a single-TM domain polypeptide that forms a transporter complex with Ost-alpha protein, which is a 7-transmembrane (TM) domain containing protein. This heterodimerisation is required for the delivery of the complex to the plasma membrane. The OSTalpha-OSTbeta complex serves as a multispecific transporter that may participate in cellular uptake of bile acids, some endogenous and exogenous steroids, and eicosanoids. It functions via a facilitated diffusion mechanism. Interestingly, this transporter also transports dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate (PREGS), which are major excitatory neurosteroids. This suggests a possible function for OSTalpha-OSTbeta complex in the brain []. | Short Name: | OSTbeta |
| GO Term | Gene Name |
|---|---|
| GO:0005215 | IPR029387 |
| GO:0046982 | IPR029387 |
| GO:0015721 | IPR029387 |
| GO:0005886 | IPR029387 |
| GO Term | Gene Name |
|---|---|
| GO:0005215 | IPR029387 |
| GO:0046982 | IPR029387 |
| GO:0015721 | IPR029387 |
| GO:0005886 | IPR029387 |
