Protein Domain : IPR005407

Type:  Family Name:  Potassium channel subfamily K member 9
Description:  TASK is a member of the TWIK-related (two P-domain) K+channel family identified in human tissues []. It is widely distributed, being particularly abundant in the pancreas and placenta, but it is also found inthe brain, heart, lung and kidney. Its amino acid identity to TWIK-1 and TREK-1 is rather low, being about 25-28%. However, it is thought to share the same topology of four TM segments, with two P-domains. TASK is very sensitive to variations in extracellular pH in the physiological range, changing from fully-open to closed in approximately 0.5 pH units around pH 7.4. Thus, it may well be a biological sensor of external pH variations.Potassium channel subfamily K member 9 (KCNK9, also known as TASK3) is a pH-dependent, voltage-insensitive, background potassium channel protein [, ]. Short Name:  KCNK9

0 Child Features

1 Contains

DB identifier Type Name
IPR013099 Domain Potassium channel domain

1 Cross References

Identifier
PR01585

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005267 IPR005407
GO:0071805 IPR005407
GO:0016021 IPR005407

3 Ontology Annotations

GO Term Gene Name
GO:0005267 IPR005407
GO:0071805 IPR005407
GO:0016021 IPR005407

1 Parent Features

DB identifier Type Name
IPR003092 Family Two pore domain potassium channel, TASK family

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9312005
            11042359
            11431495