Protein Domain : IPR027257

Type:  Family Name:  Mitogen-activated protein kinase kinase kinase 12
Description:  MAP3K12 (also known as leucine-zipper protein kinase (ZPK), dual leucine zipper-bearing kinase (DLK) or MAPK-upstream kinase (MUK)) is a MAPKKK class protein kinase that induces JNK/SAPK activation. MAP3K12 is known to interact with MUK-binding inhibitory protein (MBIP). MBIP contains two tandem leucine-zipper-like motifs; MBIP interacts with one of the two leucine-zipper-like motifs of MAP3K12 and inhibits the activity of MAP3K12 to induce JNK/SAPK activation [, ]. MAP3K12 is autophosphorylated on Ser/Thr in cytosol under basal conditions, and dephosphorylated when membrane-associated. Short Name:  MAPKKK12
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0 Child Features

0 Contains

1 Cross References

Identifier
PIRSF500741

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004709 IPR027257
GO:0000186 IPR027257
GO:0007254 IPR027257
GO:0046777 IPR027257

4 Ontology Annotations

GO Term Gene Name
GO:0004709 IPR027257
GO:0000186 IPR027257
GO:0007254 IPR027257
GO:0046777 IPR027257

1 Parent Features

DB identifier Type Name
IPR017419 Family Mitogen-activated protein kinase kinase kinase 12/13

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10801814
            14697235