Protein Domain : IPR017428

Type:  Family Name:  Interleukin-1 receptor-associated kinase 4
Description:  This entry represents Interleukin-1 receptor-associated kinase 4 (IRAK4) (). IRAK4 is required for the efficient recruitment of IRAK1 to the interleukin-1 (IL-1) receptor complex following IL-1 engagement, triggering intracellular signalling cascades leading to transcriptional up-regulation and mRNA stabilisation [, ]. IRAK4 phosphorylates IRAK1. Pellino-2 may be a substrate for both IRAK1 and IRAK4 []. Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) []. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Defects in IRAK4 are also the cause of IRAK4 deficiency []. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children. Short Name:  IL-1_rcpt-assoc_kin4
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0 Child Features

1 Contains

DB identifier Type Name
IPR011029 Domain Death-like domain

1 Cross References

Identifier
PIRSF038189

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0000287 IPR017428
GO:0004674 IPR017428
GO:0006468 IPR017428
GO:0007165 IPR017428

4 Ontology Annotations

GO Term Gene Name
GO:0000287 IPR017428
GO:0004674 IPR017428
GO:0006468 IPR017428
GO:0007165 IPR017428

0 Parent Features

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18524972
            17548806
            12860405
            16950813
            15069404