Protein Domain : IPR005293

Type:  Family Name:  Antigen peptide transporter 2
Description:  The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembrane domain (TMD). Eukaryotic ABC proteins are usually organised either as full transporters (containing two NBDs and two TMDs), or as half transporters (containing one NBD and one TMD), that have to form homo- or heterodimers in order to constitute a functional protein [].This entry represents Tap2 (also known as antigen peptide transporter 2), which is an eukaryotic protein belonging to the ABC transporter family. It plays a crucial role in the processing and presentation of the MHC class I-restricted antigens. It is a half transporter that forms a complex with Tap1. This complex translocates antigens from the cytoplasm to the endoplasmic reticulum for loading onto MHC class I molecules []. Short Name:  Tap2/ABCB3
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0 Child Features

2 Contains

DB identifier Type Name
IPR003439 Domain ABC transporter-like
IPR017871 Conserved_site ABC transporter, conserved site

2 Cross Referencess

Identifier
PTHR24221:SF160
PR01897

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0005524 IPR005293
GO:0015440 IPR005293
GO:0042287 IPR005293
GO:0019885 IPR005293
GO:0030176 IPR005293
GO:0042825 IPR005293

6 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR005293
GO:0015440 IPR005293
GO:0042287 IPR005293
GO:0019885 IPR005293
GO:0030176 IPR005293
GO:0042825 IPR005293

1 Parent Features

DB identifier Type Name
IPR013305 Family ABC transporter Tap-like

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11441126
            21205905