Type: | Family | Name: | Pendrin |
Description: | Pendrin (SLC26A4) is a Cl-/anion exchanger that can transport bicarbonate [, ], iodide [, ] and thiocyanate []. It is essential for cortical collecting duct (CCD) bicarbonate secretion in the kidney, and it is also involved in NaCl balance and blood pressure regulation. Pendrin-mediated anion exchange in the CCD is regulated at the transcriptional level by uroguanylin, a peptide hormone produced mainly in the intestinal mucosa []. | Short Name: | Pendrin |