Protein Domain : IPR030270

Type:  Family Name:  Voltage-dependent anion-selective channel protein 1
Description:  VDAC-1 is a voltage dependent anion channel that mediates the flow of metabolites and ions across the outer mitochondrial membrane. VDAC-1 appeares to be a pro-apoptotic protein through oligomerisation []. It is implicated in cell death induction for its ability to interact with BAX, a protein belonging to the BCL-2 protein family. BAX plays a role in apoptosis and mitochondrial function regulation via multiple protein-protein interactions with BCL-2, BAK, BID or other members of the family [, ]. Voltage dependent anion channels (VDACs) or porins by analogy with bacterial porins, are pore-forming proteins associated with mitochondria, although they are also present in the endoplasmic reticulum (ER) [] and plasma membrane []. In mammals, three VDAC isoforms have been identified: VDAC1 to 3. They have a very similar predicted structure, consisting of a 19 amphipathic beta-strands barrel with an N-terminal alpha-helix in the central pore [, ]. The channel opening faces both the cytosol and mitochondrial intermembrane space [, ]. They play a major role in cellular energetic metabolism due to its ability to allow the exchange of molecules between the cytosol and the mitochondrial intermembrane space. They may also play a role in cell death. However, several mouse gene knock out studies show that VDACs are dispensable for both MPT (mitochondrial permeability transition) and Bcl-2 family member-driven cell death [, ]. Short Name:  VDAC1
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR11743:SF13

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0008308 IPR030270
GO:0006820 IPR030270
GO:0005741 IPR030270
GO:0016021 IPR030270

4 Ontology Annotations

GO Term Gene Name
GO:0008308 IPR030270
GO:0006820 IPR030270
GO:0005741 IPR030270
GO:0016021 IPR030270

1 Parent Features

DB identifier Type Name
IPR001925 Family Porin, eukaryotic type

0 Proteins

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18755977
            20184885
            15238267
            11259441
            17209561
            24908397
            20138821
            24642864
            25087640
            17417626