4 GO Annotations
| GO Term | Gene Name |
|---|---|
| GO:0008308 | IPR030277 |
| GO:0006820 | IPR030277 |
| GO:0005739 | IPR030277 |
| GO:0016021 | IPR030277 |
4 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0008308 | IPR030277 |
| GO:0006820 | IPR030277 |
| GO:0005739 | IPR030277 |
| GO:0016021 | IPR030277 |
| Type: | Family | Name: | Voltage-dependent anion-selective channel protein 2 |
| Description: | VDAC2 is a voltage dependent anion channel that mediates the flow of metabolites and ions across the outer mitochondrial membrane. It may play a role in mitochondrial apoptosis through its involvement in the mitochondrial recruitment of BAK, a protein belonging to the BCL-2 protein family [, , ].Voltage dependent anion channels (VDACs) or porins by analogy with bacterial porins, are pore-forming proteins associated with mitochondria, although they are also present in the endoplasmic reticulum (ER) [] and plasma membrane []. In mammals, three VDAC isoforms have been identified: VDAC1 to 3. They have a very similar predicted structure, consisting of a 19 amphipathic beta-strands barrel with an N-terminal alpha-helix in the central pore [, ]. The channel opening faces both the cytosol and mitochondrial intermembrane space [, ]. They play a major role in cellular energetic metabolism due to its ability to allow the exchange of molecules between the cytosol and the mitochondrial intermembrane space. They may also play a role in cell death. However, several mouse gene knock out studies show that VDACs are dispensable for both MPT (mitochondrial permeability transition) and Bcl-2 family member-driven cell death [, ]. | Short Name: | VDAC2 |
| GO Term | Gene Name |
|---|---|
| GO:0008308 | IPR030277 |
| GO:0006820 | IPR030277 |
| GO:0005739 | IPR030277 |
| GO:0016021 | IPR030277 |
| GO Term | Gene Name |
|---|---|
| GO:0008308 | IPR030277 |
| GO:0006820 | IPR030277 |
| GO:0005739 | IPR030277 |
| GO:0016021 | IPR030277 |
