Protein Domain : IPR030703

Type:  Family Name:  Histone deacetylase 5
Description:  Histone deacetylases (HDACs) modulate the acetylation level of histone and non-histone proteins to regulate chromatin structure and gene expression. Histone deacetylase 5 (HDAC5) undergoes signal-dependent translocation between the nucleus and cytoplasm, which is regulated in part by calcium/calmodulin-dependent kinase (CaMK)-mediated phosphorylation. HDAC5 and its intracellular translocation are key effectors of multiple pathways that regulate neuronal cell apoptosis []. HDAC5 has been identified as a inflammatory mediator in rheumatoid arthritis, as its expression is suppressed by inflammatory cytokines which leads to activation of fibroblast-like synoviocytes [, ]. Short Name:  Histone_deacetylase_5
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10625:SF57

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0004407 IPR030703
GO:0016575 IPR030703
GO:0040029 IPR030703
GO:0005634 IPR030703
GO:0005737 IPR030703

5 Ontology Annotations

GO Term Gene Name
GO:0004407 IPR030703
GO:0016575 IPR030703
GO:0040029 IPR030703
GO:0005634 IPR030703
GO:0005737 IPR030703

1 Parent Features

DB identifier Type Name
IPR017320 Family Histone deacetylase class II, eukaryotic

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            25661252
            25452308
            25512013