Protein Domain : IPR017326

Type:  Family Name:  Peptidase S1A, polyserase-2
Description:  This entry represents serine peptidases that belong to MEROPS petidase family S1A (clan PA(S)). They are a novel enzyme with three tandem serine protease domains in a single polypeptide chain. Polyserase-2 (polyserine protease-2) is the second identified human enzyme with several tandem serine protease domains. The first serine protease domain contains all characteristic features of these enzymes, whereas the second and third domains lack one residue of the catalytic triad of serine proteases and are predicted to be catalytically inactive. Both full-length polyserase-2 and its first serine protease domain hydrolyse synthetic peptides used for assaying serine proteases. The activity of the isolated domain was greater than that of the entire protein, suggesting that the two catalytically inactive serine protease domains of polyserase-2 may modulate the activity of the first domain. Polyserase-2 is expressed in foetal kidney, adult skeletal muscle, liver, placenta, prostate, and heart, and tumour cell lines derived from lung and colon adenocarcinomas. In contrast to polyserase-1, this protein is a secreted enzyme whose three protease domains remain as an integral parts of a single polypeptide chain []. Short Name:  Pept_S1A_polyserase-2

0 Child Features

1 Contains

DB identifier Type Name
IPR018114 Active_site Peptidase S1, trypsin family, active site

1 Cross References

Identifier
PIRSF037933

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0004252 IPR017326

1 Ontology Annotations

GO Term Gene Name
GO:0004252 IPR017326

1 Parent Features

DB identifier Type Name
IPR001314 Family Peptidase S1A, chymotrypsin-type

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15536082