Protein Domain : IPR030327

Type:  Family Name:  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Description:  SERCA2 belongs to the IIA subfamily of P-type ATPases, whose members are Ca2+ ATPases that catalyse the hydrolysis of ATP coupled with the transport of calcium across the membrane. SERCA2 is a specialised Ca2+ pump, known as SERCA pump, which is localised in sarcoplasmic reticulum and endoplasmic reticulum []. Mutations in the SERCA2 gene cause Darier disease, which is characterised by loss of adhesion between suprabasal epidermal keratinocytes (acantholysis) and abnormal keratinization (dyskeratosis) []. There are several alternatively spliced SERCA2 isoforms in humans that are involved in maintaining normal heart function []. Short Name:  SERCA2
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR24093:SF234

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0005388 IPR030327
GO:0005524 IPR030327
GO:0070588 IPR030327
GO:0005783 IPR030327
GO:0016021 IPR030327
GO:0033017 IPR030327

6 Ontology Annotations

GO Term Gene Name
GO:0005388 IPR030327
GO:0005524 IPR030327
GO:0070588 IPR030327
GO:0005783 IPR030327
GO:0016021 IPR030327
GO:0033017 IPR030327

1 Parent Features

DB identifier Type Name
IPR005782 Family P-type ATPase, subfamily IIA, SERCA-type

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            20423818
            19962989
            17286271