Protein Domain : IPR030697

Type:  Family Name:  Ras-related protein Rab29
Description:  Ras-related protein Rab29 (also known as RAB7L) is a small GTPase that regulates phagocytosis and traffic from the Golgi to the lysosome []. It is associated with trans-Golgi network (TGN) and is essential for maintaining the integrity of the TGN. Together with LRRK2, it plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner []. Rab29 and other Rab-family GTPases such as Rab29 and Rab32 can be cleaved by GtgE, which is an effector protein from Salmonella Typhimurium that modulates trafficking of the Salmonella-containing vacuole (SCV). By targeting these GTPases, GtgE allows survival of the pathogen by preventing the delivery of antimicrobial factors to the SCV []. Short Name:  Rab29
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR24073:SF315

0 Found In

8 GO Annotations

GO Term Gene Name
GO:0003924 IPR030697
GO:0005525 IPR030697
GO:0006895 IPR030697
GO:0035526 IPR030697
GO:0051223 IPR030697
GO:0005794 IPR030697
GO:0005802 IPR030697
GO:0031982 IPR030697

8 Ontology Annotations

GO Term Gene Name
GO:0003924 IPR030697
GO:0005525 IPR030697
GO:0006895 IPR030697
GO:0035526 IPR030697
GO:0051223 IPR030697
GO:0005794 IPR030697
GO:0005802 IPR030697
GO:0031982 IPR030697

1 Parent Features

DB identifier Type Name
IPR003579 Family Small GTPase superfamily, Rab type

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            24788816
            22042847