Protein Domain : IPR030487

Type:  Family Name:  DNA (cytosine-5)-methyltransferase 3A
Description:  In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) []. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes []. DNMT3A exists in an autoinhibitory form that can be activated by the histone H3 tail in a DNMT3L-independent manner []. DNMT3A has been linked to cancers [, , ]. Short Name:  DNMT3A
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR23068:SF10

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0009008 IPR030487
GO:0006306 IPR030487
GO:0010468 IPR030487

3 Ontology Annotations

GO Term Gene Name
GO:0009008 IPR030487
GO:0006306 IPR030487
GO:0010468 IPR030487

1 Parent Features

DB identifier Type Name
IPR001525 Family C-5 cytosine methyltransferase

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10555141
            21304883
            25416277
            25416276
            25383530
            25358520