| Type: | Family | Name: | Junction plakoglobin |
| Description: | Plakoglobin (gamma-catenin) is an armadillo repeat protein found in adherens junctions, where they interact with the cytoplasmic domain of classical cadherins and with alpha-catenin. It is also a structural constituent of desmosomes, where it binds to the cytoplasmic domains of the desmosomal cadherins, desmogleins and desmocollins []. It acts as a substrate for vascular endothelial protein tyrosine phosphatase (VE-PTP) and is required by it to stimulate vascular endothelial (VE)-cadherin function in endothelial cells. It can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton [].Plakoglobin has multiple functions as a a cell adhesion molecule and may also have a role as transcriptional activator in Wnt signalling [, ]. | Short Name: | Plakoglobin |
| GO Term | Gene Name |
|---|---|
| GO:0005198 | IPR030461 |
| GO:0045294 | IPR030461 |
| GO:0045296 | IPR030461 |
| GO:0002159 | IPR030461 |
| GO:0007155 | IPR030461 |
| GO:0005913 | IPR030461 |
| GO:0016342 | IPR030461 |
| GO Term | Gene Name |
|---|---|
| GO:0005198 | IPR030461 |
| GO:0045294 | IPR030461 |
| GO:0045296 | IPR030461 |
| GO:0002159 | IPR030461 |
| GO:0007155 | IPR030461 |
| GO:0005913 | IPR030461 |
| GO:0016342 | IPR030461 |
