| Type: | Family | Name: | Coiled-coil protein DIX1 |
| Description: | Ccd1 (coiled-coil-DIX1), axin, and dishevelled (Dvl or Dsh) are three DIX domain proteins that play important roles in Wnt signaling, one of the major developmental signaling pathways. Ccd1 forms homomeric and heteromeric complexes with Dvl and Axin [], and is a positive regulator of Wnt signalling []. It inhibits JNK activation both by Axin and by Dvl []. The C-terminal DIX domain plays an important role in the regulation of signal transduction through homo-oligomerization and protein complex formation with other DIX domain-containing proteins []. | Short Name: | Ccd1 |
