| Type: | Family | Name: | Cofilin 1 |
| Description: | This entry represents cofilin 1. Cofilins bind to F-actin and exhibit pH-sensitive F-actin depolymerising activity. They are important for mitosis and plays a role in the regulation of cell morphology and cytoskeletal organisation [, ]. The activities of cofilin and ADF (actin-depolymerising factor) are inhibited through phosphorylation by kinases (LIMKs and TESKs); the inactive cofilin and ADF can be re-activated through dephosphorylation by phophatases including SSH and chronophin. The proper regulation of cofilin/ADF activities through control of phosphorylation by LIMKs and SSHs is critical for neurite extension []. | Short Name: | Cofilin_1 |
