1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR013307 | Family | Superantigen, staphylococcal/streptococcal toxin, bacterial |
| Type: | Family | Name: | Staphylococcus aureus exotoxin |
| Description: | Staphylococcus aureusis a well-characterised and specialised prokaryotic human pathogen, expressing a variety of virulence factors to enablesuccessful infection of the host. Symptoms usually manifest in cases of food poisoning, pyrogenic fever and toxic shock syndrome, and can provelethal in immunocompromised patients. Of all the exotoxins secreted from the bacterial cell, superantigens and hemolysins are amongst the moststudied. Recently, a novel gene cluster encoding several new superantigen exotoxin- like virulence factors has been isolated from S. aureus []. Although thegene products elicit classic symptoms of pyrogenic fever and food poisoning in susceptible animal models, their overall similarity to sequences of knownsuperantigens and hemolysins is limited. However, they do share regions of higher similarity in several key functional domains, leading thesemoieties to be termed Staphylococcal Exotoxin-like Enterotoxins (SETs), 15 of which have so far been isolated from pathogenic strains [].The crystal structure of S. aureus Set3 enterotoxin has been resolved to 1.9A by means of X-ray crystallography. It reveals the two-fold structurecharacteristic of the superantigen superfamily: an N-terminal OB fold and a C-terminal beta-grasp domain, joined by an N-terminal alpha-helix.However, it differs significantly in several places. Beta-strands 6 and 7 protrude from the molecular surface in the beta-grasp domain, unlike theusually smooth surface of other superantigens. Also, there appears to be a large, saddle-shaped positively-charged surface capable of bindingnegatively-charged molecules, such as DNA. | Short Name: | Staph_exotoxin |
| DB identifier | Type | Name |
|---|---|---|
| IPR013307 | Family | Superantigen, staphylococcal/streptococcal toxin, bacterial |
