3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0005267 | IPR008073 |
| GO:0071805 | IPR008073 |
| GO:0016020 | IPR008073 |
1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR003092 | Family | Two pore domain potassium channel, TASK family |
| Type: | Family | Name: | Potassium channel subfamily K member 15 |
| Description: | TASK is a member of the TWIK-related (two P-domain) K+channel family identified in human tissues []. It is widely distributed, being particularly abundant in the pancreas and placenta, but it is also found inthe brain, heart, lung and kidney. Its amino acid identity to TWIK-1 and TREK-1 is rather low, being about 25-28%. However, it is thought to share the same topology of four TM segments, with two P-domains. TASK is very sensitive to variations in extracellular pH in the physiological range, changing from fully-open to closed in approximately 0.5 pH units around pH 7.4. Thus, it may well be a biological sensor of external pH variations.TASK-5 is expressed in the pancreas, liver, kidney, lung, ovary, testis and heart. It requires another as yet unidentified partner subunit to form functional channels in the plasma membrane, or it may form a channel in an intracellular organelle []. | Short Name: | TASK5 |
| GO Term | Gene Name |
|---|---|
| GO:0005267 | IPR008073 |
| GO:0071805 | IPR008073 |
| GO:0016020 | IPR008073 |
| DB identifier | Type | Name |
|---|---|---|
| IPR003092 | Family | Two pore domain potassium channel, TASK family |
