Protein Domain : IPR030702

Type:  Family Name:  Ras-related protein Rab14
Description:  Ras-related protein Rab14 is a small GTPase that mediates endocytic recycling and functions in phagosome maturation [, ]. Rab14 and its exchange factor FAM116 regulates the specific endocytic transport of ADAM10 and thereby N-cadherin shedding and cell motility [, ]. Rab14 regulates claudin-2 trafficking, which is required for epithelial morphogenesis []. It regulates apical targeting in polarised epithelial cells []. Rab14 also regulates the interaction of phagosomes with early endocytic compartments and the maturation of macrophage phagosomes containing the fungal pathogen Candida albicans []. Drosophila Rab14 mediates phagocytosis in the immune response to Staphylococcus aureus []. Short Name:  Rab14
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR24073:SF185

0 Found In

9 GO Annotations

GO Term Gene Name
GO:0003924 IPR030702
GO:0005525 IPR030702
GO:0006895 IPR030702
GO:0032456 IPR030702
GO:0042742 IPR030702
GO:0090382 IPR030702
GO:0005802 IPR030702
GO:0045335 IPR030702
GO:0055037 IPR030702

9 Ontology Annotations

GO Term Gene Name
GO:0003924 IPR030702
GO:0005525 IPR030702
GO:0006895 IPR030702
GO:0032456 IPR030702
GO:0042742 IPR030702
GO:0090382 IPR030702
GO:0005802 IPR030702
GO:0045335 IPR030702
GO:0055037 IPR030702

1 Parent Features

DB identifier Type Name
IPR003579 Family Small GTPase superfamily, Rab type

0 Proteins

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            22595670
            18429929
            24694596
            25644001
            24119134
            22595666
            22569897