Protein Domain : IPR030770

Type:  Family Name:  Signal-induced proliferation-associated 1-like protein 1
Description:  SIPA1-like proteins share sequence similarity with signal-induced proliferation-associated protein 1 (SIPA1), which is a GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 [, ]. This entry represents SIPA1L1 (also known as SPAR), which has been identified as a Rap-specific GTPase-activating protein. SPAR is a postsynaptic regulator of synaptic morphology and function []. It interacts with the scaffold protein PSD-95 and forms a complex with PSD-95 and NMDA receptors in brain. It regulates F-Actin organisation and recruits PSD-95 to F-actin []. Short Name:  SIPA1L1

0 Child Features

0 Contains

1 Cross References

Identifier
PTHR15711:SF10

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005096 IPR030770
GO:0031532 IPR030770
GO:0043087 IPR030770
GO:0048814 IPR030770

4 Ontology Annotations

GO Term Gene Name
GO:0005096 IPR030770
GO:0031532 IPR030770
GO:0043087 IPR030770
GO:0048814 IPR030770

0 Parent Features

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9346962
            15310461
            11502259
            18723513