| Type: | Family | Name: | Matrilin-4 |
| Description: | Matrilin family consists of four non-collagenous extracellular matrix (ECM) proteins []. Matrilin-1 and matrilin-3 are expressed mainly in cartilage, while matrilin-2 and matrilin-4 are widely distributed in many connective tissues []. Typical matrilin has the similar domain structure with two von Willebrand factor A-like (VWA) domains interconnected by a variable number of epidermal growth factor-like (EGF) domains. The subunits form trimers or tetramers via a C-terminal alpha-helical coiled-coil domain [].Matrilin-4 contains two vWFA-like domains linked by four epidermal growth factor-like modules and a potential coiled-coil alpha-helical oligomerisation domain at the C terminus []. Matrilin-4 is processed in the secretory pathway by aggrecanase ADAMTS-5 []. | Short Name: | Matrilin-4 |
