Protein Domain : IPR030761

Type:  Family Name:  Monocarboxylate transporter 8
Description:  Monocarboxylate transporter 8 (MCT8), also known as SLC16A2, belongs to the MCT family. It is a thyroid hormone transporter []. Mutations in the MCT8 gene is associated with psychomotor retardation [, ].Monocarboxylate transporters (MCTs) catalyse the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane [, ]. All of the MCT family (also known as SLC16 solute carrier family) members share conserved sequence motifs. They are are predicted to have 12-transmembrane helices (TMs) with intracellular C and N termini and a large cytosolic loop between TMs 6 and 7 []. Short Name:  MCT8
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR11360:SF123

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0015349 IPR030761
GO:0070327 IPR030761
GO:0005887 IPR030761

3 Ontology Annotations

GO Term Gene Name
GO:0015349 IPR030761
GO:0070327 IPR030761
GO:0005887 IPR030761

1 Parent Features

DB identifier Type Name
IPR011701 Family Major facilitator superfamily

0 Proteins

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9425115
            22131303
            12871948
            15488219
            18636565