| Type: | Family | Name: | Virion membrane protein, poxvirus L1-related |
| Description: | The four families of large eukaryotic DNA viruses, Poxviridae, Asfarviridae, Iridoviridae, and Phycodnaviridae, referred to collectively as nucleocytoplasmic large DNA viruses or NCLDV, have all been shown to have a lipid membrane, in spite of the major differences in virion structure. The paralogous genes L1R and F9L encode membrane proteins that have a conserved domain architecture, with a single, C-terminal transmembrane helix, and an N-terminal, multiple-disulphide-bonded domain. The conservation of the myristoylated, disulphide-bonded protein L1R/F9L in most of the NCLDV correlates with the conservation of the thiol-disulphide oxidoreductase E10R which, in vaccinia virus, is required for the formation of disulphide bonds in L1R and F9L []. | Short Name: | Virion_mem_poxvirus_L1 |
